How tiny structures inside cells form and function
Molecular determinants of condensate assembly in heterogeneous environments
This research helps us understand how tiny structures inside our cells organize themselves, which is important for many body functions and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11170697 on NIH RePORTER |
What this research studies
Our bodies rely on tiny structures within cells, called biomolecular condensates, to organize important molecules for various functions like making proteins and sending signals. These condensates form through a natural process called phase separation, similar to oil and water separating. When these condensates don't form correctly, it can contribute to diseases like neurodegenerative conditions or viral infections. This project uses computer models and calculations to figure out how these structures assemble and what controls their stability in the complex environment of a living cell.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future applications could benefit individuals with neurodegenerative diseases or viral infections.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental understanding could pave the way for new ways to address diseases where these cellular structures malfunction, such as neurodegenerative disorders.
How similar studies have performed: The concept of biomolecular condensates and phase separation is a rapidly growing field, with many researchers contributing to our understanding of these fundamental biological processes.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Jacobs, William Monroe — Princeton University
- Study coordinator: Jacobs, William Monroe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.