How tiny parts of our DNA control our health
The role of histone tails in chromatin structure and gene regulation
['FUNDING_OTHER'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11109733
This project explores how small parts of our DNA packaging, called histone tails, help control our genes, which can affect conditions like cancer and heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11109733 on ClinicalTrials.gov |
What this research studies
Our bodies are made of cells, and inside each cell is DNA, which contains all our genetic instructions. This DNA is carefully packaged into structures called chromatin, with special proteins called histones acting like spools. Tiny parts of these histones, called histone tails, stick out and can be modified, influencing how our genes are turned on or off. When these histone tails don't work correctly, it can lead to serious health problems, including certain cancers and heart conditions. This work aims to understand exactly how these histone tails function so we can better address diseases caused by their malfunction.
Who could benefit from this research
Good fit: This foundational research is relevant to patients living with conditions such as cancer, cardiac diseases, and metabolic disorders, as it seeks to understand the root causes of these illnesses.
Not a fit: Patients whose conditions are not related to gene regulation or chromatin structure may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to correct gene regulation problems that cause diseases like cancer and metabolic disorders.
How similar studies have performed: This research builds upon existing knowledge of chromatin but aims to fill significant gaps in understanding the precise role of histone tails in gene regulation.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORRISON, EMMA ANTONINA — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MORRISON, EMMA ANTONINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiac Diseases, Cardiac Disorders