How tiny motor proteins guide chromosomes during cell division
Mechanisms of microtubule motors and chromosome segregation
Researchers are working to understand how molecular motor proteins move and organize chromosomes so that errors that drive cancer can be reduced.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11259484 on NIH RePORTER |
What this research studies
From a patient's viewpoint, the team is studying the tiny motor proteins (called kinesins) that pull and position chromosomes when cells divide. They will use a mix of single-molecule experiments, detailed live-cell imaging, and targeted genetic changes to see how these motors work in cells, tissues, and whole organisms. The goal is to connect the basic mechanics inside cells to the chromosome errors seen in many tumors. Results come from lab experiments using cells and model organisms rather than a treatment trial.
Who could benefit from this research
Good fit: People with cancers characterized by chromosome missegregation or aneuploidy who are willing to provide tissue samples or participate in related translational research would be most relevant.
Not a fit: People without cancer or whose tumors do not show chromosome segregation errors are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new targets for therapies that prevent chromosome missegregation and slow cancer progression.
How similar studies have performed: Previous laboratory studies have clarified some kinesin functions, but turning those findings into effective cancer treatments remains largely unproven.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Stumpff, Jason K — University of Vermont & St Agric College
- Study coordinator: Stumpff, Jason K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.