How tiny exosome packages help heart cells signal after injury
Exosomes as mediators of cardiac injury and repair
Researchers are looking at tiny particles called exosomes to learn how heart cells talk to each other after injury so people with heart damage might heal better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11098628 on NIH RePORTER |
What this research studies
If you take part, researchers would study tiny membrane bubbles called exosomes that heart cells release after injury and see how those messages affect healing. They will compare exosomes from injured and healthy heart tissue and examine effects on cells in the heart and in distant organs like bone marrow and fat. Lab experiments on cells and tissue samples will be used to track how those signals change after injury. The goal is to find specific exosome signals that could be targeted to improve recovery after a heart attack.
Who could benefit from this research
Good fit: Ideal candidates are people who have experienced recent heart injury (for example a heart attack) or who can donate relevant blood or tissue samples for research.
Not a fit: People without heart injury or those unwilling to provide samples are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: This work could point to new ways to help the heart repair itself after injury.
How similar studies have performed: Early research shows exosomes can carry helpful or harmful signals after heart damage, but turning that into patient treatments is still new and largely unproven.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kishore, Raj — Temple Univ of the Commonwealth
- Study coordinator: Kishore, Raj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.