How tiny cell-packages carry BK potassium channels
Molecular identity of exosomal BK channels
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11231215
This work finds out whether tiny packets released by cells (exosomes) carry BK potassium channels that help them survive changing salt levels and protect heart tissue after low blood flow.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11231215 on ClinicalTrials.gov |
What this research studies
Researchers used computer searches to identify ion channel genes and a novel near-field electrophysiology method to show functional BK channels exist in exosomes. They test whether exosomes with BK survive better in different ionic environments and whether those exosomes influence the content and integrity of the vesicles. Animal heart injury models (ischemia-reperfusion) are used to see if exosomal BK reduces damage to cardiac tissue. The work combines lab-based electrical recordings, molecular analysis, and preclinical heart experiments to connect basic mechanisms to possible heart protection.
Who could benefit from this research
Good fit: People who have had or are at high risk for heart ischemia-reperfusion injury (for example recent heart attack or certain heart surgeries) would be the most relevant candidates for future related trials.
Not a fit: Patients with conditions unrelated to heart ischemia or those seeking immediate clinical treatment are unlikely to get direct benefit from this preclinical work.
Why it matters
Potential benefit: If successful, this could point to new ways to protect the heart from damage after a heart attack or to develop exosome-based delivery of protective therapies.
How similar studies have performed: Prior work shows exosomes can carry protective molecules and help heart repair, but finding functional ion channels like BK in exosomes and using them for cardioprotection is a novel, early-stage approach.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, HARPREET — OHIO STATE UNIVERSITY
- Study coordinator: SINGH, HARPREET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.