How tiny blood vessels in different organs react during sepsis
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.
This work looks at how the small blood vessels that line organs behave during sepsis to help find ways to protect organs and improve recovery for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11322575 on NIH RePORTER |
What this research studies
Researchers will combine samples from patients with advanced lab tools such as gene-expression profiling and CRISPR-based methods to study how endothelial cells (the cells that line tiny blood vessels) differ between organs during sepsis. They aim to map organ-specific changes that lead to leak, clotting, and low oxygen in tissues. The program will use patient-derived samples together with lab models to test which molecular pathways drive harmful endothelial responses. Findings will be used to identify targets for new treatments that could be tested in future clinical trials.
Who could benefit from this research
Good fit: Children hospitalized with sepsis or septic shock who can provide consent/assent for blood or tissue sampling (and whose families agree to participate) would be the most likely participants.
Not a fit: People without sepsis, outpatients, or patients too unstable to provide samples are unlikely to participate or receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could point to new treatments that protect organs, reduce organ failure, and improve survival and recovery for people with sepsis.
How similar studies have performed: Gene-expression profiling has helped identify immune subtypes in sepsis, but organ-specific studies of endothelial cells in patients are newer and remain largely untested clinically.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Atreya, Mihir R — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Atreya, Mihir R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.