How TIMELESS and PARP1 work together to keep DNA stable during replication
The interplay of TIMELESS and PARP1 in DNA replication fork stability
This study looks at how two proteins, TIMELESS and PARP1, work together to protect our DNA during its copying process, which is important for preventing damage that can lead to cancer, and the findings could help improve future cancer treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10875531 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that protect DNA during replication, focusing on how the proteins TIMELESS and PARP1 interact to maintain the stability of DNA replication forks. By understanding how these proteins function, the research aims to uncover critical insights into the processes that prevent DNA damage and chromosomal abnormalities, which are often linked to cancer. The study employs biochemical techniques to analyze the interactions and roles of these proteins in DNA replication, providing a foundation for potential therapeutic strategies. Patients may benefit from advancements in cancer treatment that arise from a better understanding of DNA repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with BRCA1/2 mutations or other genetic predispositions to cancer.
Not a fit: Patients with cancers unrelated to DNA replication errors or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers associated with DNA replication errors.
How similar studies have performed: Other research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Kim, Hyungjin — State University New York Stony Brook
- Study coordinator: Kim, Hyungjin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.