How TIMELESS and PARP1 work together to keep DNA replication stable
The interplay of TIMELESS and PARP1 in DNA replication fork stability
This study is looking at how two proteins, TIMELESS and PARP1, help keep our DNA safe and stable when cells divide, which is important for preventing issues like cancer, and it hopes to find new ways to treat these problems in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11034675 on NIH RePORTER |
What this research studies
This research investigates the roles of two proteins, TIMELESS and PARP1, in maintaining the stability of DNA replication forks, which are crucial for accurate DNA copying during cell division. By using advanced live-cell imaging technology, the study aims to observe how these proteins interact and affect cellular processes such as cell cycle progression, proliferation, and response to DNA damage. Patients may benefit from insights gained about how disruptions in these processes can lead to diseases like cancer, potentially guiding future therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic predispositions to cancer or those undergoing treatment for malignancies.
Not a fit: Patients with conditions unrelated to DNA replication or damage repair may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions related to DNA damage and replication errors, such as cancer.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, making this approach promising but still exploring specific interactions between TIMELESS and PARP1.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Kim, Hyungjin — State University New York Stony Brook
- Study coordinator: Kim, Hyungjin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.