How ticks manage their immune responses and metabolism
Metabolic Pathways Regulating Tick Immune Responses
['FUNDING_P01'] · UNIV OF MARYLAND, COLLEGE PARK · NIH-11112745
This study looks at how ticks can safely feed on blood for a long time without getting sick from germs, and it aims to find ways to help control ticks and prevent diseases they spread.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MARYLAND, COLLEGE PARK (nih funded) |
| Locations | 1 site (COLLEGE PARK, UNITED STATES) |
| Trial ID | NIH-11112745 on ClinicalTrials.gov |
What this research studies
This research investigates the unique physiological adaptations of ticks that allow them to feed on blood for extended periods while tolerating harmful microbes. It focuses on understanding how tick-borne pathogens interact with the tick's immune system and metabolic pathways. By studying the signaling networks activated by host-derived molecules, the research aims to uncover how ticks regulate their immune responses and metabolism during blood meals. This knowledge could lead to the development of new strategies for controlling tick populations and preventing tick-borne diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas where tick-borne diseases are prevalent, particularly those who may be at higher risk of exposure.
Not a fit: Patients who do not live in tick-endemic regions or those who are not at risk for tick-borne diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for controlling tick populations and reducing the incidence of tick-borne diseases in humans.
How similar studies have performed: Other research has shown success in understanding immune responses in insects and mammals, but the specific connection between metabolism and immunity in ticks is still being explored.
Where this research is happening
COLLEGE PARK, UNITED STATES
- UNIV OF MARYLAND, COLLEGE PARK — COLLEGE PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEDRA, JOAO — UNIV OF MARYLAND, COLLEGE PARK
- Study coordinator: PEDRA, JOAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.