How tick-borne pathogens affect each other and their mammalian hosts
Interactions of tick-borne pathogens, Borrelia burgdorferi and Babesia microti with the mammalian host using rodent model of co-infections
This study is looking at how two tick-borne germs, Borrelia burgdorferi and Babesia microti, work together in mice to see how they affect each other and the immune system, which could help us better understand and treat people who get both infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rbhs-New Jersey Medical School NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project ID | NIH-10467070 on NIH RePORTER |
What this research studies
This research investigates the interactions between two tick-borne pathogens, Borrelia burgdorferi and Babesia microti, using a rodent model to understand how these infections affect each other and the host's immune response. By studying co-infections in mice that exhibit symptoms similar to humans, the research aims to uncover the mechanisms behind the more severe symptoms observed in patients with both infections. The findings could lead to improved diagnostic and treatment strategies for those affected by these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Lyme disease or babesiosis, particularly those experiencing co-infections.
Not a fit: Patients who do not have Lyme disease or babesiosis, or those who are not experiencing symptoms related to these infections, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment options for patients suffering from Lyme disease and babesiosis.
How similar studies have performed: Previous studies have shown varying results in murine models regarding co-infections, indicating that this area of research is still developing and holds potential for new insights.
Where this research is happening
Newark, United States
- Rbhs-New Jersey Medical School — Newark, United States (Active)
Researchers
- Principal investigator: Parveen, Nikhat — Rbhs-New Jersey Medical School
- Study coordinator: Parveen, Nikhat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.