How thyroid hormones affect metabolism and obesity
Official title: Metabolic and xenobiotic control of thyroid hormone metabolism
Funded at University of Texas Med Br Galveston · NIH-11259338 · Data updated 2026-11-12
This study looks at how a temporary boost in a thyroid hormone called T3 during early development affects metabolism and fat processing in the liver, which could help us understand how these changes might influence weight and health later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | January 15, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $438,571 |
| NIH project number | 7R01DK077148-12 |
| Project ID | NIH-11259338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may have metabolic disorders or obesity-related conditions.
✕Less likely to help
Patients over 21 years old or those without metabolic issues may not benefit from this research.
What this research studies
This research investigates the role of thyroid hormones, specifically T3, in regulating metabolism and its impact on conditions like obesity. It focuses on how a brief increase in T3 during early development influences gene expression and metabolic processes in the liver. By studying genetically modified mice, the researchers aim to understand the long-term effects of thyroid hormone signaling on fat metabolism and liver function. The findings could provide insights into how early hormonal changes can affect health outcomes later in life.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity and related metabolic disorders.
How similar studies have gone: Previous research has shown that early hormonal influences can significantly impact metabolic health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Bianco, Antonio C — University of Texas Med Br Galveston
- Study coordinator: Bianco, Antonio C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.