How therapeutic HIV vaccination changes T-cell responses
Official title: Multi-omic understanding of the transformed host T-cell response to HIV following therapeutic vaccination
Funded at University of California at Davis · NIH-11391004 · Data updated 2026-11-12
This project looks at whether therapeutic HIV vaccines can create new, better-working T cells in people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | May 22, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,575,640 |
| NIH project number | 5P01AI178375-04 |
| Project ID | NIH-11391004 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are on stable antiretroviral therapy and willing to receive a therapeutic vaccine and provide blood and follow-up samples.
✕Less likely to help
People without HIV or those with medical conditions that prevent vaccination or safe participation are unlikely to benefit directly from this project.
What this research studies
If you join, researchers will collect blood and immune cells before and after a therapeutic HIV vaccine and run multiple lab tests that measure gene activity, cell metabolism, and T-cell receptors. They will track whether vaccination expands existing T cells or brings up new T-cell clones and will test how well those cells can multiply and respond. The team will compare immune and metabolic patterns to find which conditions lead to stronger, more functional T-cell responses. Findings will be used to guide vaccine design and strategies that could improve immune control of HIV.
Why it matters
Potential benefit: If successful, the work could help design vaccines or strategies that expand new, more effective T cells to improve viral control in people with HIV.
How similar studies have gone: Previous therapeutic HIV vaccine trials have had limited success at controlling the virus, but detailed immune-monitoring and multi-omic approaches are increasingly showing which T-cell changes matter.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Hartigan-O'connor, Dennis J. — University of California at Davis
- Study coordinator: Hartigan-O'connor, Dennis J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.