How the X-linked gene UTX shapes natural killer cells in men and women
Sex Differences in NK Cells Mediated by X-linked UTX
This project examines whether differences in the X-linked gene UTX make natural killer (NK) cells work differently in males versus females, which can change how people fight viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11372642 on NIH RePORTER |
What this research studies
You would hear that researchers are comparing NK cells from males and females using both mouse models and human blood samples to see how UTX levels differ. They delete UTX specifically in NK cells in mice to reproduce the male pattern and measure changes in NK cell numbers and their production of the antiviral signal IFN-γ. The team also looks at how UTX changes chromatin (DNA packaging) around genes that control NK cell fitness and function. Findings could point to biological reasons for sex differences in viral illness susceptibility.
Who could benefit from this research
Good fit: Ideal participants would be adults of any sex willing to donate blood samples, especially people with known or suspected exposure to common viruses like cytomegalovirus (CMV).
Not a fit: People with health issues unrelated to viral immunity or who need immediate clinical treatment are unlikely to gain direct benefit from participating in this basic immunology research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to boost NK cell antiviral responses or personalize immune therapies based on sex.
How similar studies have performed: Prior studies have shown sex differences in immune responses and that UTX controls gene programs, but connecting UTX directly to sex-biased NK antiviral function is a novel application.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Su, Maureen a — University of California Los Angeles
- Study coordinator: Su, Maureen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.