How the vagus nerve affects pancreas secretion through specific neurons
Official title: The impact of the neuronal Kv7.2 current on cholinergic control of pancreas secretion
Funded at University of Miami School of Medicine · NIH-11068974 · Data updated 2026-11-12
This study is looking at how the vagus nerve affects insulin and digestive enzyme release from the pancreas, which could help us understand diabetes and other pancreatic issues better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $45,574 |
| NIH project number | 1F30DK139715-01A1 |
| Project ID | NIH-11068974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes or other pancreatic disorders who may benefit from improved therapeutic strategies.
✕Less likely to help
Patients without pancreatic disorders or those not affected by autonomic nervous system dysfunction may not receive any benefit from this research.
What this research studies
This research investigates how the vagus nerve influences the secretion of insulin and digestive enzymes from the pancreas. It focuses on the role of intrapancreatic neurons, which are believed to process cholinergic signals from the vagus nerve. By studying the activation of specific receptors and the resulting neuronal activity, the research aims to clarify the mechanisms behind pancreatic function and its regulation. This could lead to a better understanding of conditions like diabetes and other pancreatic disorders.
Why it matters
Potential benefit: If successful, this research could improve treatments for diabetes and other pancreatic disorders by enhancing our understanding of how nerve signals regulate pancreatic function.
How similar studies have gone: While the specific focus on intrapancreatic neurons is novel, similar research on the role of the vagus nerve in other organ systems has shown promising results.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Levi, Noah Joseph — University of Miami School of Medicine
- Study coordinator: Levi, Noah Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.