How the uterus prepares for embryo implantation
Post-Transcriptional Regulation of Embryo Implantation
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11093402
This study is looking at how certain proteins in the uterus help prepare it for a successful pregnancy, especially how they respond to hormones, to find out why some pregnancies don’t stick, with the hope of creating better treatments for women who have trouble during early pregnancy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11093402 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular changes in the uterus that are necessary for a successful embryo implantation. It focuses on understanding how specific proteins, particularly the splicing factor SF3B1, influence the way RNA is processed in response to hormones like estrogen and progesterone. By studying these processes, the research aims to uncover why some pregnancies fail at the implantation stage, which could lead to new treatments for women experiencing early pregnancy loss. Patients may benefit from insights that could improve fertility treatments and pregnancy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing difficulties with embryo implantation or recurrent early pregnancy loss.
Not a fit: Patients who are not trying to conceive or those with conditions unrelated to implantation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies to prevent early pregnancy loss and improve fertility treatments.
How similar studies have performed: Other research has shown promising results in understanding the role of hormonal signaling in reproductive health, making this area of investigation both relevant and potentially impactful.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOMMAGANI, RAMAKRISHNA — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: KOMMAGANI, RAMAKRISHNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.