How the Ubiquitin System Controls Cell Functions
Mechanisms of Cell Regulation and Manipulation by the Ubiquitin System
This study is looking at how a system in our cells helps break down proteins and keeps our cells healthy, which is important for people with diseases like cancer and neurodegenerative disorders, and it also explores how certain bacteria might affect this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11090639 on NIH RePORTER |
What this research studies
This research investigates how the ubiquitin system regulates protein degradation and cellular functions, which is crucial for maintaining healthy cells. It explores the dynamic processes of ubiquitin and related proteins, focusing on their roles in various human diseases, including neurodegenerative disorders and cancers. The study involves examining how these proteins are modified and how they interact with cellular machinery, particularly under different nutrient conditions. Additionally, it looks at how certain bacteria can influence these processes through their own enzymes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodegenerative diseases or cancers that may be influenced by the ubiquitin system.
Not a fit: Patients with conditions unrelated to protein degradation or the ubiquitin system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to the ubiquitin system, potentially improving outcomes for patients with neurodegenerative diseases and cancers.
How similar studies have performed: Previous research has shown promising results in targeting the ubiquitin system for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Hochstrasser, Mark W — Yale University
- Study coordinator: Hochstrasser, Mark W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.