How the tumor environment affects mitochondrial behavior in cancer spread
(PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
This study looks at how the area around tumors affects the energy-producing parts of cancer cells, which could help us understand why breast cancer spreads in different ways and lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10693122 on NIH RePORTER |
What this research studies
This research investigates how the environment surrounding tumors influences the behavior of mitochondria, which are crucial for cancer cell metabolism and spread. By using advanced imaging techniques and specially designed tumor models, the study aims to understand the interactions between tumor cells and their surrounding stroma. The goal is to uncover how these interactions lead to different patterns of cancer metastasis, which could ultimately inform new treatment strategies for patients with breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-cancerous conditions or those whose cancer has already metastasized extensively may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that prevent or reduce cancer metastasis, improving survival rates for patients.
How similar studies have performed: Previous research has shown that understanding the tumor microenvironment can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Shen, Keyue — University of Southern California
- Study coordinator: Shen, Keyue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.