How the tiny fibers that hold the eye's lens work
Structural, mechanical, and cell biological properties of the ciliary zonule
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11306092
Learning how genetic faults make the small fibers that hold the lens weak or misshapen so people with inherited lens‑dislocation and related eye problems can be better helped in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11306092 on ClinicalTrials.gov |
What this research studies
This project models inherited zonule disorders (Marfan syndrome, Weill‑Marchesani syndrome, and isolated ectopia lentis) in mice to study the fibers that suspend the lens. Researchers use advanced imaging and material‑testing methods to measure the structure and viscoelastic (stretch and recoil) properties of those fibers when key proteins are mutated or missing. They will track eye pressure changes in newborn mice and pressurize developing eyes in the lab to see whether pressure affects how the fibers form. The team will also study the enzyme LOXL1 to understand whether its cross‑links give the zonule fibers their strength.
Who could benefit from this research
Good fit: People with inherited zonule disorders or a history of lens dislocation—such as those with Marfan syndrome, Weill‑Marchesani syndrome, or isolated ectopia lentis—would be the most relevant patient group for this research.
Not a fit: Patients whose eye problems are unrelated to zonule fiber defects or those seeking immediate clinical treatment are unlikely to benefit directly from this primarily lab‑based, animal model research.
Why it matters
Potential benefit: If successful, this work could point to ways to prevent or treat lens dislocation and related complications such as cataract, glaucoma, or retinal problems by targeting the underlying fiber weakness.
How similar studies have performed: Previous genetic and proteomic studies have identified zonule components and disease links, but applying mechanical testing and developmental pressurization to explain fiber failure is a newer, less tested approach.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASSNETT, STEVEN — WASHINGTON UNIVERSITY
- Study coordinator: BASSNETT, STEVEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.