How the TCA cycle affects fat production in the body
Regulation of lipogenesis by TCA cycle metabolism
This study is looking at how our bodies make fat and how this process can change when someone has conditions like obesity, diabetes, or heart disease, to help us understand how what we eat affects our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11041158 on NIH RePORTER |
What this research studies
This research investigates the role of the TCA cycle in regulating fat production, which is crucial for maintaining normal body functions. It focuses on how the balance of certain metabolic pathways influences the availability of citrate, a key component for fat synthesis. By utilizing advanced techniques such as stable isotope tracers and analytical chemistry, the study aims to understand how these metabolic processes are altered in conditions like obesity, diabetes, and cardiovascular diseases. The findings could provide insights into how nutrition impacts fat metabolism and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity, diabetes, cardiovascular diseases, or other metabolic disorders.
Not a fit: Patients without metabolic disorders or those not affected by obesity or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity, diabetes, and related metabolic disorders.
How similar studies have performed: Previous research has shown that metabolic pathways related to the TCA cycle can significantly impact fat metabolism, suggesting that this approach has potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Burgess, Shawn C — Ut Southwestern Medical Center
- Study coordinator: Burgess, Shawn C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.