How the sympathetic nervous system affects aging in blood stem cells
Official title: Regulation of hematopoietic stem cell niche aging by the sympathetic nervous system
Funded at Albert Einstein College of Medicine · NIH-10941134 · Data updated 2026-11-12
This study is looking at how getting older affects the blood-making stem cells in our bodies and how signals from our nerves might help keep these cells healthy, with the hope of finding new ways to treat blood disorders that come with age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $566,022 |
| NIH project number | 1R01HL174801-01 |
| Project ID | NIH-10941134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing blood disorders or diminished immune function.
✕Less likely to help
Patients with acute blood disorders unrelated to aging may not benefit from this research.
What this research studies
This research investigates how aging impacts hematopoietic stem cells (HSCs), which are crucial for blood regeneration and immune function. It explores the role of the sympathetic nervous system (SNS) in regulating the environment around these stem cells, particularly focusing on how nerve signals can influence their health and function. By examining the effects of β3-adrenergic agonists, the study aims to understand how to rejuvenate aging stem cells and improve their regenerative capacity. Patients may benefit from insights into new treatments for blood disorders linked to aging.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance blood regeneration and immune function in older patients.
How similar studies have gone: Previous research has shown promising results in rejuvenating stem cell function through sympathetic nervous system modulation, indicating potential for success in this approach.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Marianovich, Maria — Albert Einstein College of Medicine
- Study coordinator: Marianovich, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.