How the surrounding fat tissue communicates with blood vessels
PVAT mechanics in health and disease
['FUNDING_P01'] · MICHIGAN STATE UNIVERSITY · NIH-10980460
This study is looking at how the fat around your blood vessels talks to them and how changes in pressure and stiffness can affect that communication, which could help us understand more about keeping your heart and blood vessels healthy.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10980460 on ClinicalTrials.gov |
What this research studies
This research investigates the role of perivascular adipose tissue (PVAT) in communicating with blood vessels, focusing on how mechanical signals from the blood vessel can influence the behavior of PVAT. The study aims to understand both the passive and active roles of PVAT in maintaining vascular health, particularly how it responds to pressure and changes in stiffness. By examining these interactions, the research seeks to uncover new insights into how PVAT can affect blood vessel function and overall cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiovascular conditions or those at risk for such diseases, particularly those with obesity-related complications.
Not a fit: Patients without cardiovascular issues or those who do not have significant adipose tissue surrounding their blood vessels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing cardiovascular diseases by targeting the interactions between blood vessels and surrounding adipose tissue.
How similar studies have performed: While the specific mechanisms of PVAT communication are still being explored, related research has shown promising results in understanding the role of adipose tissue in cardiovascular health.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WATTS, STEPHANIE W — MICHIGAN STATE UNIVERSITY
- Study coordinator: WATTS, STEPHANIE W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.