How the surrounding cells affect melanoma spread
Project 2: Contribution of the Stromal Microenvironment to Early Dissemination
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10900747
This study is looking at how certain cells in the body, called cancer-associated fibroblasts, help melanoma spread early on, and it's for anyone interested in understanding more about how this type of skin cancer behaves and grows.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10900747 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cancer-associated fibroblasts (CAFs) in the early spread of melanoma. By using genetically engineered mouse models, the study aims to understand how signals between melanoma cells and CAFs contribute to tumor heterogeneity and metastatic behavior. The researchers will manipulate specific genes in both melanoma cells and CAFs to observe their interactions and effects on cancer progression. This approach could reveal important insights into the mechanisms driving melanoma metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma, particularly those in the early stages of the disease.
Not a fit: Patients with advanced melanoma or those who do not have a diagnosis of melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prognostic markers and therapeutic targets for melanoma treatment.
How similar studies have performed: Other research has shown promising results in understanding the role of CAFs in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ITO, MAYUMI — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: ITO, MAYUMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Control, Cancer Control Science, Cancerous, Cancers