How the structure of tendon tissue affects inflammation
Official title: Extracellular Matrix Regulation of Inflammatory Signaling in Tendon
Funded at University of Michigan at Ann Arbor · NIH-11067850 · Data updated 2026-11-12
This study is looking at how the structure of tendon tissue affects inflammation in people with tendon pain, using special lab techniques to better understand how these changes might help improve treatments for tendon injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 5, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $332,904 |
| NIH project number | 5R01AR083343-02 |
| Project ID | NIH-11067850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing tendinopathy or related musculoskeletal issues.
✕Less likely to help
Patients with acute tendon injuries or those not experiencing any tendon-related symptoms may not benefit from this research.
What this research studies
This research investigates the relationship between the extracellular matrix (ECM) of tendon tissue and inflammatory signaling in tendinopathy. By using advanced 3D cell culture techniques, the study aims to understand how the stiffness of the ECM influences the inflammatory response of tendon cells. The researchers will analyze patient-derived fibroblasts to observe their behavior in a more realistic environment that mimics the conditions in the body. This approach could provide insights into the mechanisms behind tendon injuries and chronic pain, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from tendon injuries and related inflammatory conditions.
How similar studies have gone: Previous research has shown promising results in understanding tendon behavior through 3D culture models, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Abraham, Adam Christopher — University of Michigan at Ann Arbor
- Study coordinator: Abraham, Adam Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.