How the structure of fat tissue affects diabetes
Extracellular matrix-adipocyte metabolic crosstalk and diabetes
This study is looking at how the structure around fat cells affects diabetes, especially in military Veterans, to find new ways to help manage the condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11044150 on NIH RePORTER |
What this research studies
This research investigates the role of the extracellular matrix (ECM) in fat tissue and its impact on metabolic dysfunction related to diabetes, particularly in military Veterans. The study aims to understand how changes in the ECM, influenced by factors like advanced glycation end-products, affect the metabolism of fat cells (adipocytes) and contribute to insulin resistance. By exploring these mechanisms, the researchers hope to develop new strategies to manipulate fat tissue properties to improve diabetes management. Patients may be involved in trials that assess these new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are military Veterans who are experiencing obesity and type II diabetes.
Not a fit: Patients without obesity or those who do not have type II diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve insulin sensitivity and metabolic health in individuals with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of the extracellular matrix in metabolic diseases, suggesting that this approach could yield significant insights.
Where this research is happening
Ann Arbor, United States
- Veterans Health Administration — Ann Arbor, United States (Active)
Researchers
- Principal investigator: O'rourke, Robert W — Veterans Health Administration
- Study coordinator: O'rourke, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.