How the structure of DNA affects immune cell function
Chromatin architecture as a regulator of dendritic cell function
This study is looking at how the structure of DNA in immune cells called dendritic cells affects their ability to help your body fight infections, and it hopes to find ways to improve immune responses for better health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11042209 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin architecture in dendritic cells, which are crucial for initiating immune responses. By examining how specific proteins influence the organization of DNA within these cells, the study aims to understand how this affects their ability to present antigens and produce important signaling molecules like interferons. The research involves advanced techniques to analyze the three-dimensional structure of chromatin and its impact on gene expression and immune function. Patients may benefit from insights gained into how immune responses can be better regulated or enhanced.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with immune system disorders or those undergoing treatments that affect immune function.
Not a fit: Patients with stable, well-functioning immune systems may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, potentially benefiting those with infections or cancers.
How similar studies have performed: Previous research has shown promising results in understanding chromatin's role in immune cell function, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Reizis, Boris — New York University School of Medicine
- Study coordinator: Reizis, Boris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.