How the spread of viruses affects their genetic diversity and evolution
Role of spatial structure in shaping viral population diversity and evolution
This study is looking at how the way the flu virus spreads in the body affects its ability to change and adapt, which could help us understand how new strains of the virus come about and how we can better manage them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10888977 on NIH RePORTER |
What this research studies
This research investigates how the spatial structure of viral spread influences the genetic diversity and evolution of the influenza A virus. By using a combination of computational models, cell culture experiments, and ferret models, the study aims to understand how factors like viral characteristics and host responses impact viral evolution. The researchers hypothesize that the way a virus spreads within a host can create random bottlenecks that affect its adaptability. This could lead to a better understanding of how new viral strains emerge and how they might be controlled.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals who are at risk for influenza infections, particularly those with compromised immune systems or underlying health conditions.
Not a fit: Patients who are not at risk for influenza or who have already been vaccinated may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and controlling influenza outbreaks.
How similar studies have performed: Other research has shown that understanding viral evolution can significantly improve public health responses to epidemics, indicating that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lowen, Anice C — Emory University
- Study coordinator: Lowen, Anice C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.