How the small intestine forms its loops
Molecular control of mechanical forces driving buckling morphogenesis of the small intestine
This research helps us understand how the small intestine develops its normal looped shape, which is important for healthy digestion.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11099869 on NIH RePORTER |
What this research studies
Our small intestine needs to fold into loops to fit properly inside the abdomen. When this looping doesn't happen correctly, it can lead to serious birth defects. This project looks at how tiny molecular signals work together with physical forces to create these essential loops. We want to uncover the biological details that guide this folding process, which is crucial for the healthy development of many organs.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals, especially children, affected by congenital disorders involving the small intestine's development.
Not a fit: Patients without congenital intestinal disorders are unlikely to see direct benefit from this specific basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how to prevent or treat congenital disorders where the small intestine doesn't form correctly.
How similar studies have performed: Previous work has already identified a key signaling pathway, BMP, that helps control gut looping, providing a strong foundation for this project.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Nerurkar, Nandan L — Columbia Univ New York Morningside
- Study coordinator: Nerurkar, Nandan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.