How the RYBP protein affects glioblastoma tumor cells
Official title: Determining the Mechanisms of RING1- and YY1-Binding Protein (RYBP) Function and Dysregulation in Glioblastoma Cells
Funded at Winthrop University · NIH-11194243 · Data updated 2026-11-12
Researchers will test whether restoring the RYBP protein can reduce aggressive behaviors of glioblastoma cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winthrop University NIH-funded |
| Lab location | 1 site (Rock Hill, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $192,456 |
| NIH project number | 5R16NS141721-02 |
| Project ID | NIH-11194243 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with glioblastoma or other high-grade brain tumors who want to follow research on tumor biology and potential future treatments.
✕Less likely to help
Patients without glioblastoma or those seeking immediate treatment advances are unlikely to get direct benefit from this lab-based work.
What this research studies
From a patient's point of view, scientists will add the RYBP protein back into glioblastoma cells and, separately, reduce RYBP in normal-like brain cells to see what changes. They will grow single-cell clones and measure effects on cell survival, movement, and invasion in the lab. The team will use RNA sequencing and chromatin-based experiments to find which genes RYBP controls. These experiments use cultured glioblastoma cell lines and immortalized astrocytes in a laboratory at Winthrop University.
Why it matters
Potential benefit: If successful, this work could point to new drug targets or strategies that restore RYBP function to slow tumor growth or boost other therapies for glioblastoma patients.
How similar studies have gone: Previous research shows RYBP is reduced and can act as a tumor suppressor in several cancers, but applying these findings specifically to glioblastoma is relatively new and not yet proven in patients.
Where this research is happening
-
Winthrop University
Rock Hill, United States Active
Researchers
- Principal investigator: Stovall, Daniel Brooks — Winthrop University
- Study coordinator: Stovall, Daniel Brooks
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.