How the RNA regulator Morrbid affects allergic reactions
Long Non-Coding RNAs in Allergy
Researchers are looking at whether a molecule called Morrbid controls immune cells that cause allergic reactions, which could help people with allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11164541 on NIH RePORTER |
What this research studies
This work focuses on a long non-coding RNA called Morrbid that seems to shape the immune cells responsible for allergic responses. Scientists will use genetically altered mice and single-cell RNA sequencing to see which T cells depend on Morrbid and how it changes their behavior. The team aims to trace the molecular steps by which Morrbid influences Th2 and Tfh13 cells that drive high‑affinity IgE and anaphylaxis. Findings may point to new targets to reduce severe allergic reactions in the future.
Who could benefit from this research
Good fit: People with IgE‑mediated allergic diseases or a history of severe allergic reactions could be the most likely to benefit from future therapies stemming from this work.
Not a fit: People with non‑allergic conditions or allergies that are not driven by Th2/IgE immune pathways may not see direct benefit.
Why it matters
Potential benefit: If successful, the research could identify new molecular targets to prevent or reduce severe allergic reactions like anaphylaxis.
How similar studies have performed: Previous studies show some long non‑coding RNAs regulate immune cells and preliminary mouse data link Morrbid to type 2 responses, but applying lncRNA targeting to allergy is a relatively new approach.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Williams, Adam — Northwestern University
- Study coordinator: Williams, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.