How the pulmonary artery changes with age
Age-related Changes in the Pulmonary Artery
This study looks at how the pulmonary artery changes as we get older, focusing on its stiffness and the makeup of its cells, to help us understand how aging can affect lung health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10689318 on NIH RePORTER |
What this research studies
This research investigates the structural and functional changes in the pulmonary artery as people age. By examining the stiffness of the artery and the changes in collagen, the study aims to understand how these factors contribute to age-related vascular issues. The research involves advanced techniques like 2-photon imaging and single-cell RNA sequencing to analyze the genetic expression of cells in the pulmonary artery. The findings could help model how aging affects pulmonary artery function and health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 21 years of age, who may be experiencing vascular issues.
Not a fit: Patients under 21 years old or those without age-related vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of age-related pulmonary artery conditions, potentially improving health outcomes for older adults.
How similar studies have performed: Other research has shown success in understanding vascular aging, but this specific approach focusing on the pulmonary artery is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Manning, Edward P — Yale University
- Study coordinator: Manning, Edward P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.