How the protein FAM210A affects the heart
Deciphering the role of FAM210A in cardiac physiopathology
This project looks at how the protein FAM210A supports heart muscle cells and what that means for adults with heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11123297 on NIH RePORTER |
What this research studies
As a patient, I learned that researchers are studying a protein called FAM210A that helps mitochondria in heart cells work. They remove or reduce FAM210A in mouse heart cells and use lab methods like CRISPR, biochemical tests, and imaging to measure mitochondrial calcium, membrane potential, and oxidative stress. They also examine human heart tissue and sequencing data to see whether FAM210A is reduced in people with ischemic heart failure. The team maps FAM210A interactions with proteins such as LETM1 to understand how it helps heart cells cope with stress.
Who could benefit from this research
Good fit: Adults with ischemic heart disease, heart failure, or suspected mitochondrial cardiomyopathy would be the most relevant people to provide tissue samples or join future trials based on this work.
Not a fit: People without heart disease, children, or patients whose heart problems stem from unrelated causes may not receive direct benefit from these findings.
Why it matters
Potential benefit: If successful, this work could point to new ways to protect heart mitochondria and reduce damage from heart attacks or mitochondrial cardiomyopathy.
How similar studies have performed: Previous research linking mitochondrial dysfunction, calcium handling, and oxidative stress to heart failure has identified promising targets, but targeting FAM210A itself is a newer and less-tested approach.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yao, Peng — University of Rochester
- Study coordinator: Yao, Peng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.