How the protein CREG1 affects blood sugar control
Role of CREG1 in metabolic homeostasis
This work looks at whether changes in the protein CREG1 cause insulin resistance or reduce insulin release in adults with type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11291814 on NIH RePORTER |
What this research studies
If you have type 2 diabetes, this project aims to explain whether lower or absent CREG1 makes insulin less effective and reduces insulin secretion. Researchers will use lab-grown liver and pancreatic cells and genetically modified mice where CREG1 is turned off or increased to track insulin receptor recycling and insulin granule movement. They will use CRISPR gene tools and viral methods to change CREG1 levels and study the effects, including how a high-fat diet alters CREG1. The goal is to link basic cell and animal findings to mechanisms that matter for human blood sugar control.
Who could benefit from this research
Good fit: Adults with type 2 diabetes or people at high risk for insulin resistance are the population most likely to benefit from findings derived from this work.
Not a fit: People with type 1 diabetes or diabetes caused primarily by non–insulin-resistance mechanisms may not benefit directly from these results.
Why it matters
Potential benefit: If successful, this could point to new ways to boost insulin action or protect insulin-producing cells for people with type 2 diabetes.
How similar studies have performed: Previous lab and animal studies have shown CREG1 affects insulin signaling and glucose control, but translating these findings into human treatments remains untested.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Li, Shaohua — Rutgers Biomedical and Health Sciences
- Study coordinator: Li, Shaohua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.