How the protective layers around the brain influence its development
Official title: Meninges Specification and Cellular Crosstalk to the Developing Brain
Funded at University of Colorado Denver · NIH-10994174 · Data updated 2026-11-12
This study is looking at how special cells in the protective layers around the brain help guide the growth and movement of brain cells, which could help us understand and improve treatments for conditions that affect brain development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 7, 2022 |
| Project end | October 6, 2025 |
| Funding year | 2025 |
| Award (this year) | $35,748 |
| NIH project number | 5F31NS130940-03 |
| Project ID | NIH-10994174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting brain development, particularly those related to the FOXC1 gene.
✕Less likely to help
Patients with fully developed and functioning CNS without any neurodevelopmental disorders may not benefit from this research.
What this research studies
This research investigates the role of non-neural cells, specifically fibroblasts in the meninges, in the development of the central nervous system (CNS). It focuses on how these cells communicate with neural cells to guide processes like neuronal migration and neurogenesis. By studying genetic mutations that affect these interactions, the research aims to uncover the molecular signaling pathways involved in brain development. This could lead to a better understanding of neurodevelopmental disorders and how to address them.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or treating neurodevelopmental disorders by targeting the signaling pathways involved in brain development.
How similar studies have gone: Previous research has shown that understanding cellular interactions in brain development can lead to significant advancements in treating neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Como, Christina N — University of Colorado Denver
- Study coordinator: Como, Christina N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.