How the process of mitophagy helps maintain healthy tissues
Mechanisms of mitophagy in tissue health and homeostasis
['FUNDING_OTHER'] · WAYNE STATE UNIVERSITY · NIH-11017113
This study is looking at how a process called mitophagy helps keep our cells healthy by getting rid of damaged parts, using fruit flies to learn more about how this works in the body, especially for diseases related to mitochondria.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-11017113 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitophagy, a process that removes damaged mitochondria, in maintaining tissue health. By using the fruit fly Drosophila melanogaster as a model organism, the researchers aim to understand how mitophagy functions in living tissues, particularly in the context of diseases that involve mitochondrial damage. The study focuses on genetic factors that influence mitophagy and seeks to uncover the mechanisms that support tissue function and health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by metabolic or neurodegenerative diseases that involve mitochondrial damage.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating diseases associated with mitochondrial dysfunction, such as metabolic and neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial quality control mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INSOLERA, RYAN — WAYNE STATE UNIVERSITY
- Study coordinator: INSOLERA, RYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.