How the PP2A enzyme affects immune cells in lupus
Phosphatases in lupus
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11328851
Looking at whether changing the PP2A enzyme can restore healthy T cell metabolism and reduce inflammation in people with lupus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11328851 on ClinicalTrials.gov |
What this research studies
Researchers will examine how the enzyme PP2A controls enzymes that power T cell metabolism using lab experiments and mouse models that mimic lupus. They will test whether a metabolic molecule called gluconolactone can lower inflammation and systemic autoimmunity in mice. The team will map which metabolic enzymes PP2A alters and how those changes impair regulatory T cell (Treg) function. Results will link enzyme activity, cell metabolism, and immune control in lupus to guide potential new therapies.
Who could benefit from this research
Good fit: People with systemic lupus erythematosus (SLE), especially those with active disease or T cell–linked symptoms, would be the most relevant group for future trials or sample donation.
Not a fit: People without autoimmune disease or whose lupus is driven primarily by non–T cell mechanisms may not benefit from these specific metabolic approaches.
Why it matters
Potential benefit: If successful, this work could point to new metabolic-targeted treatments that restore Treg function and reduce organ inflammation in people with lupus.
How similar studies have performed: Previous research has linked PP2A to human and mouse lupus and shown metabolism affects Treg function, but using gluconolactone as a treatment approach is relatively new.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSOKOS, GEORGE C — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: TSOKOS, GEORGE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.