How the organization of the genome affects brain cell development
Official title: Chromatin factor regulation of neuroblast progenitor genome dynamics
Funded at Columbia University Health Sciences · NIH-10981559 · Data updated 2026-11-12
This study is looking at how the way genes are arranged in brain cells affects their ability to turn into different types of neurons, which is important for healthy brain development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $454,717 |
| NIH project number | 1R01GM152663-01A1 |
| Project ID | NIH-10981559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurodevelopmental disorders or those interested in understanding brain development.
✕Less likely to help
Patients with fully developed neural systems and no neurodevelopmental concerns may not receive direct benefits from this research.
What this research studies
This research investigates how the three-dimensional organization of the genome within neural progenitor cells influences their ability to develop into various types of neurons. By examining the regulatory mechanisms that control this genomic organization, the study aims to uncover how neural progenitors transition through different states of competence, which ultimately affects brain tissue structure and function. The research employs advanced techniques in genome sequencing and analysis to gather data on how these processes occur in living organisms, particularly in the context of brain development.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development disorders and potential therapeutic strategies for neurodevelopmental conditions.
How similar studies have gone: Previous research has shown promising results in understanding genome organization and its impact on cellular function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kohwi, Minoree — Columbia University Health Sciences
- Study coordinator: Kohwi, Minoree
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.