How the order of genetic mutations affects the development of leukemia
Impact of mutational order on molecular mechanisms of oncogenesis
This study is looking at how the order of genetic changes affects the development of acute myeloid leukemia (AML), and it's for anyone interested in understanding this type of cancer better, with hopes of finding new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11035132 on NIH RePORTER |
What this research studies
This research investigates how the sequence in which genetic mutations occur influences the development of acute myeloid leukemia (AML). By using advanced gene editing techniques, the study aims to create models of AML that mimic the disease in humans. The researchers will analyze how specific mutations interact and the timing of their occurrence to understand their impact on cancer progression. This could lead to insights into the mechanisms of leukemia and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of leukemia or those without any genetic predisposition to leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with acute myeloid leukemia by targeting the specific genetic changes that drive the disease.
How similar studies have performed: Previous research has shown promising results in understanding cancer evolution through genetic mutation analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Papapetrou, Eirini — Icahn School of Medicine at Mount Sinai
- Study coordinator: Papapetrou, Eirini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.