How the oral microbiome affects inflammation in people with HIV
Official title: Role of the oral microbiome in driving local and systemic inflammation in HIV
Funded at University of California Los Angeles · NIH-10894809 · Data updated 2026-11-12
This study is looking at how bacteria in the mouth might affect inflammation in people with HIV, and it hopes to find ways to improve health by understanding the connection between oral and gut bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $757,421 |
| NIH project number | 5R01DE032624-02 |
| Project ID | NIH-10894809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing chronic inflammation or related health complications.
✕Less likely to help
Patients who are not living with HIV or those without any signs of inflammation may not benefit from this research.
What this research studies
This research investigates the role of the oral microbiome in contributing to inflammation in individuals living with HIV. It aims to understand how bacteria from the mouth may travel to the gut and influence systemic inflammation, which can lead to various health complications. By examining the connections between oral and gut bacteria, the study seeks to uncover mechanisms that could help reduce inflammation and improve health outcomes for HIV patients. The research will involve analyzing microbiome samples and assessing their impact on inflammation-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing inflammation and associated health issues in HIV patients.
How similar studies have gone: While research on the oral microbiome in general is growing, studies specifically linking it to HIV-related inflammation are limited, making this approach relatively novel.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Fulcher, Jennifer — University of California Los Angeles
- Study coordinator: Fulcher, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.