How the nucleus affects cell movement in tight spaces
Official title: Nuclear mechanobiology in confined migration
Funded at Cornell University · NIH-11045717 · Data updated 2026-11-12
This study looks at how the structure of the cell nucleus affects its ability to move through tight spaces, which is important for things like cancer spreading and healing wounds, and it aims to help us understand how changes in the nucleus can influence how cells behave.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $364,176 |
| NIH project number | 5R35GM153257-02 |
| Project ID | NIH-11045717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve abnormal cell migration, such as cancer patients or those with chronic wounds.
✕Less likely to help
Patients with conditions unrelated to cell migration or those who are not undergoing treatment for cancer or wound healing may not benefit from this research.
What this research studies
This research investigates how the physical properties of the cell nucleus influence its ability to migrate through confined spaces, which is crucial for processes like cancer metastasis and wound healing. By examining how mechanical forces impact nuclear structure and function, the study aims to understand the relationship between nuclear deformation and cellular migration. The research employs advanced techniques to analyze cell behavior in three-dimensional environments, focusing on how changes in the nucleus can affect gene expression and cellular functions. This could lead to insights into how certain cells are better equipped to move through tight interstitial spaces.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer metastasis and improving wound healing.
How similar studies have gone: Previous research has shown promising results in understanding cell migration mechanics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Lammerding, Jan — Cornell University
- Study coordinator: Lammerding, Jan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.