How the nucleolar RNA exosome is regulated in cancer
Regulation of the nucleolar RNA exosome in cancer
This study is looking at how a special enzyme helps control the production of ribosomes, which are important for cell function, and how this process can go wrong in cancer; understanding this could help find new ways to treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11079483 on NIH RePORTER |
What this research studies
This research investigates the role of the nucleolar RNA exosome in regulating ribosome biogenesis, which is crucial for normal cell function and is often disrupted in cancer. The study focuses on understanding how a specific enzyme, USP36, interacts with the RNA exosome and influences the processing of ribosomal RNA. By examining the molecular mechanisms involved, the research aims to uncover new insights into how cancer cells may exploit these processes for uncontrolled growth. Patients may benefit from this research as it could lead to novel therapeutic targets for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer or other cancers linked to deregulated ribosome biogenesis.
Not a fit: Patients with cancers unrelated to ribosome biogenesis or those not diagnosed with cancer may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for anti-cancer therapies by targeting the regulation of ribosome biogenesis.
How similar studies have performed: Other research has shown promising results in targeting ribosome biogenesis in cancer, indicating that this approach may be viable.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Dai, Mu-Shui — Oregon Health & Science University
- Study coordinator: Dai, Mu-Shui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.