How the nuclear pore complex affects gene regulation and chromatin structure
Official title: MECHANISMS OF CHROMATIN STRUCTURE AND TRANSCRIPTION REGULATION BY THE NUCLEAR PORE COMPLEX
Funded at Duke University · NIH-11058396 · Data updated 2026-11-12
This study is looking at how a special part of our cells, called the nuclear pore complex, helps control how genes work and how DNA is organized, which is really important for healthy cell growth and function, especially in early development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 5, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $429,548 |
| NIH project number | 5R01GM149578-03 |
| Project ID | NIH-11058396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that involve disruptions in gene regulation and chromatin organization.
✕Less likely to help
Patients with conditions unrelated to chromatin structure or nuclear pore complex function may not benefit from this research.
What this research studies
This research investigates the role of the nuclear pore complex (NPC) in regulating gene expression and chromatin structure, which are crucial for proper cell function and development. By examining how proteins that make up the NPC interact with chromatin, the study aims to uncover the mechanisms that govern gene regulation and spatial organization within the nucleus. The research employs advanced molecular biology techniques to analyze these interactions in mammalian cells, particularly during early development. Understanding these processes could provide insights into how disruptions in nuclear structure can lead to diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene regulation and chromatin structure abnormalities.
How similar studies have gone: Previous research has shown promising results in understanding the role of nuclear structures in gene regulation, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: West, Anne Elizabeth — Duke University
- Study coordinator: West, Anne Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.