How the nuclear envelope affects cell growth and division
Official title: Regulation of Cell Cycle progression by the nuclear envelope
Funded at North Carolina State University Raleigh · NIH-11063220 · Data updated 2026-11-12
This study is looking at how stretching and pressure on cells can affect their growth and division, especially focusing on the protective layer around the cell's nucleus, and it aims to help us understand how problems in this process might be linked to diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | April 10, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $318,282 |
| NIH project number | 5R01GM147823-03 |
| Project ID | NIH-11063220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions characterized by abnormal cell proliferation, such as certain types of cancer.
✕Less likely to help
Patients with stable, non-proliferative conditions or those not experiencing issues related to cell cycle regulation may not benefit from this research.
What this research studies
This research investigates how mechanical tension on cells influences their growth and division by focusing on the nuclear envelope, which is the barrier surrounding the nucleus. The study aims to understand the molecular pathways activated when cells experience tension, particularly how these pathways affect the transition from the G1 phase to the S phase of the cell cycle. By using advanced imaging and biochemical techniques, researchers will explore how changes in nuclear shape and tension can signal cells to progress through their growth cycle. This could provide insights into how disruptions in these processes may lead to diseases such as cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to abnormal cell growth, such as cancer.
How similar studies have gone: Other research has shown promising results in understanding cell cycle regulation through mechanical signaling, indicating that this approach has potential for success.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Guilluy, Christophe Daniel — North Carolina State University Raleigh
- Study coordinator: Guilluy, Christophe Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.