How the nervous system and gut bacteria interact to cause inflammation in Hirschsprung disease
Neural interactions with the microbiome and immune system that produce inflammation in Hirschsprung disease models
This study is looking at how certain nerve systems in the gut affect people with Hirschsprung disease, which can cause ongoing bowel problems after surgery, and it hopes to find ways to improve care for those dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10884255 on NIH RePORTER |
What this research studies
This research investigates the role of the enteric and autonomic nervous systems in Hirschsprung disease, a condition where part of the bowel lacks nerve cells. Using a specially designed mouse model, the study examines how these systems interact with gut bacteria and contribute to inflammation and bowel complications. By analyzing nerve activity in the bowel, researchers aim to understand the underlying mechanisms that lead to persistent issues in patients after surgery. The findings could provide insights into better management strategies for those affected by this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with Hirschsprung disease, particularly those experiencing ongoing bowel complications.
Not a fit: Patients without Hirschsprung disease or those who do not experience bowel complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with Hirschsprung disease, potentially reducing inflammation and related complications.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between the nervous system and gut microbiome, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Smith-Edwards, Kristen Michelle — Mayo Clinic Rochester
- Study coordinator: Smith-Edwards, Kristen Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.