How the movement of dental materials affects harmful oral microbes
Official title: Pathogenesis of oral microbes triggered by the cyclic deformation of biomaterials
Funded at Temple Univ of the Commonwealth · NIH-11137239 · Data updated 2026-11-12
This study is looking at how the bending and stretching of dental materials can affect harmful germs in your mouth, like Candida albicans, to help create better dental products that lower the chances of infections like denture stomatitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $656,315 |
| NIH project number | 1R56DE034026-01 |
| Project ID | NIH-11137239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who use dental prosthetics or have a history of oral infections.
✕Less likely to help
Patients without dental prosthetics or those who do not experience oral infections may not benefit from this research.
What this research studies
This research investigates how the cyclic deformation of dental biomaterials influences the behavior of harmful oral microbes, particularly focusing on Candida albicans and other biofilms. By examining the interactions between these microbes and the surfaces of dental materials under mechanical stress, the study aims to understand the mechanisms that lead to oral infections like denture stomatitis. The research employs advanced methodologies to analyze the physical and biological factors that contribute to biofilm formation and virulence. Patients may benefit from improved dental materials that reduce the risk of infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of dental materials that significantly reduce the incidence of oral infections.
How similar studies have gone: Previous research has shown that understanding the interactions between biomaterials and oral microbes can lead to advancements in dental treatments, indicating a promising avenue for this study.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Orrego, Santiago — Temple Univ of the Commonwealth
- Study coordinator: Orrego, Santiago
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.