How the microbiome affects vaccine response and asthma in children
Microbiome Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthma
This study is looking at how the tiny germs in kids' noses and guts might affect their immune responses to vaccines and their chances of getting respiratory infections and asthma, with the hope of finding ways to better predict and prevent these issues in young children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11051826 on NIH RePORTER |
What this research studies
This research investigates the role of the microbiome in shaping immune responses to vaccines and susceptibility to respiratory infections and asthma in children. By analyzing nasal and fecal samples from a large cohort of children, the study aims to uncover how the microbiome influences these health outcomes. The research employs advanced techniques to generate detailed microbiome data, which will be paired with clinical information to identify patterns and potential therapeutic targets. The ultimate goal is to improve early prediction of asthma and respiratory infections in young children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years, particularly those with asthma or a history of respiratory infections.
Not a fit: Patients outside the age range of 0-11 years or those without respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for asthma and respiratory infections in children.
How similar studies have performed: Previous research has shown promising results in understanding the microbiome's impact on immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mohn, Bill — Boston Children's Hospital
- Study coordinator: Mohn, Bill
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.