How the microbiome affects lung immunity and aging
Modulation of epithelial memory by the microbiome
This study is looking at how getting older affects lung health and immunity, especially in older adults who are more likely to get sick from viruses, by exploring the changes in their lung cells and the bacteria living in their lungs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11059972 on NIH RePORTER |
What this research studies
This research investigates the relationship between age-related declines in lung immunity and changes in the respiratory microbiome. It focuses on older adults who are more susceptible to viral infections and adverse health outcomes. By examining the epigenetic changes in lung cells and their interactions with the microbiome, the study aims to uncover how these factors contribute to chronic inflammation and impaired immune responses. The research employs advanced techniques to analyze genetic modifications and their effects on immune function.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related declines in lung function or immunity.
Not a fit: Patients who are younger and do not have any age-related respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing lung immunity in older adults, potentially reducing their risk of viral infections.
How similar studies have performed: Other research has shown promising results in understanding the role of the microbiome in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Oh, Julia — Jackson Laboratory
- Study coordinator: Oh, Julia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.