How the microbiome affects gene activity related to dental decay
Modulation of MMPs gene expression and activity by the microbiome in caries
This study is looking at how the balance of bacteria in your mouth affects certain genes that can lead to tooth decay, and it aims to find new ways to prevent or treat cavities by understanding how these bacteria and enzymes work together.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11002810 on NIH RePORTER |
What this research studies
This research investigates how the balance between the microbiome and the host influences the expression and activity of specific genes related to dental caries, a common form of tooth decay. It focuses on understanding the role of matrix metalloproteinases (MMPs), enzymes that may be activated by changes in pH and bacterial presence, in the degradation of dental tissues. By examining the interactions between these enzymes and the oral microbiome, the research aims to uncover the mechanisms that drive caries progression and how they can be modulated. This could lead to new insights into preventing or treating dental decay.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing dental caries or those at high risk for developing tooth decay.
Not a fit: Patients with no history of dental caries or those who do not have any dental health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating dental caries, enhancing oral health for patients.
How similar studies have performed: Other research has shown promising results in understanding the role of microbiomes in various health conditions, suggesting that this approach could yield valuable insights into dental caries.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: De Mattos Pimenta Vidal, Cristina — University of Iowa
- Study coordinator: De Mattos Pimenta Vidal, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.