How the microbiome affects gene activity related to dental caries
Modulation of MMPs gene expression and activity by the microbiome in caries
This study is looking at how the bacteria in your mouth might affect certain genes related to tooth decay, with the goal of finding better ways to prevent and treat cavities, and we’d love to have patients help by sharing samples or information.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10879177 on NIH RePORTER |
What this research studies
This research investigates the relationship between the microbiome and the expression of specific genes involved in dental caries, a common dental disease. It aims to understand how the presence of certain bacteria influences the activity of matrix metalloproteinases (MMPs), which play a role in the degradation and repair of dental tissues. By examining these interactions, the study seeks to uncover mechanisms that could lead to better prevention and treatment strategies for dental caries. Patients may be involved in providing samples or data to help elucidate these complex biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults over 21 years old who are experiencing dental caries or are at risk for developing them.
Not a fit: Patients with no history of dental caries or those who have already undergone extensive dental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating dental caries, ultimately enhancing oral health.
How similar studies have performed: Previous research has shown promising results in understanding the role of microbiomes in dental health, suggesting that this approach could yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: De Mattos Pimenta Vidal, Cristina — University of Iowa
- Study coordinator: De Mattos Pimenta Vidal, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.