How the mechanical properties of cell structures affect their function
Regulation of cell function by mechanical properties of biopolymer networks and lipid bilayers
This study looks at how the materials that make up our cells and their membranes affect how cells move and work, which could help us understand diseases like atherosclerosis and cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10821392 on NIH RePORTER |
What this research studies
This research investigates how the mechanical properties of biopolymer networks and lipid bilayers influence cell function and tissue physiology. By examining the physical chemistry and dynamics of cell membranes and the structures within cells, the study aims to understand how these properties affect cellular movements and responses. The approach combines experimental techniques with theoretical models to explore the behavior of cellular components under various mechanical stresses. Patients may benefit from insights gained about cellular processes related to diseases like atherosclerosis and cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with atherosclerotic cardiovascular disease or certain types of cancer.
Not a fit: Patients with conditions unrelated to cellular mechanics or those not affected by atherosclerosis or cancer may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cell dysfunction, such as atherosclerosis and cancer.
How similar studies have performed: Other research has shown promising results in understanding cellular mechanics and their implications for disease, suggesting that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Janmey, Paul a — University of Pennsylvania
- Study coordinator: Janmey, Paul a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.