How the liver protein TrkB-T1 affects NASH (fatty liver disease)
Hepatic TrkB-T1 signaling in NASH pathogenesis and resolution
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11256735
Researchers want to find out whether a liver protein called TrkB-T1 helps cause or help heal NASH in people with fatty liver disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11256735 on ClinicalTrials.gov |
What this research studies
This project focuses on a specific liver protein, TrkB-T1, that is strongly increased in mouse and human NASH. Scientists will use diet-induced NASH mouse models and detailed single-cell and bulk RNA analyses of mouse and human liver tissue to map which cells and signals change during disease. They will change TrkB-T1 levels in liver cells in mice to see whether that makes inflammation, fat accumulation, or scarring worse or better. The team will compare those results with human liver data to identify whether TrkB-T1 could become a target for future treatments.
Who could benefit from this research
Good fit: Ideal candidates would be adults with nonalcoholic fatty liver disease or biopsy-proven NASH who might provide liver tissue or participate in future related clinical studies.
Not a fit: People without NASH or those expecting immediate treatment benefits should note this is a mechanistic research project that may not offer direct or immediate clinical benefit.
Why it matters
Potential benefit: If successful, the work could point to new targets or biomarkers that lead to better treatments or earlier detection for people with NASH.
How similar studies have performed: Previous studies have shown broad signaling changes in NASH and preliminary data indicate TrkB-T1 is upregulated in mouse and human NASH, but directly targeting hepatic TrkB-T1 is a novel and untested approach.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIN, JIANDIE D — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LIN, JIANDIE D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.